Exploring drug absorption models through particle size, dose, and confinement

This webinar introduces a dissolution−permeation model that describes particle dissolution within the concentration boundary layer adjacent to a semipermeable surface.

Control of particle size is ubiquitous in the pharmaceutical industry; however, traditional pharmaceutical assumptions of particle dissolution typically ignore particle dissolution within the length scale of the CBL. The CBL does not physically prevent particles from traveling to the semi-permeable surface (mucus, epithelial barrier, synthetic membrane, etc.), and particle dissolution can occur within the CBL thickness if the particle is sufficiently small.

We have developed a model to experimentally measure in vitro flux to predict in vivo membrane permeability.