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New therapeutic approach targets PCSK9 to regulate blood cholesterol levels

When the amount of cholesterol in the blood is too high, hypercholesterolemia can develop, causing serious damage to the arteries and cardiovascular health.

11 Jun 2025

New 3D model reveals hidden role of stem cells in sense of smell

Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered that one type of stem cell thought to be dormant may play a more significant role in preserving the sense of smell than originally believed.

11 Jun 2025

Glucocorticoid receptor plays dual role in prostate cancer progression

A recent study from the Institute of Biomedicine at the University of Eastern Finland shows that the glucocorticoid receptor can both promote and inhibit prostate cancer progression, depending on the circumstances.

11 Jun 2025

Memory neurons in rats may explain why forgetting meals leads to overeating

Researchers identify "meal memory" neurons in laboratory rats that could explain why forgetting lunch leads to overeating.

11 Jun 2025

Smelling food triggers fullness through newly found brain pathway

No more hunger after cooking? A newly identified network of nerve cells is responsible, a research group at the Max Planck Institute for Metabolism Research has discovered in mice.

11 Jun 2025

Unexpected protein production in immune cells may fuel gut inflammation

Scientists have discovered that certain immune cells — called neutrophils — can start making a protein called DUOX2 that they usually do not produce.

11 Jun 2025

Antibiotic use predicts microbiota dysbiosis in preterm infants

Antibiotic use in preterm infants is linked to gut microbiome changes, increasing susceptibility to infections and impacting long-term health outcomes.

11 Jun 2025

‘Junk food’ plant diets raise heart risk even if meat is cut out

Research shows that healthy plant-based diets lower cardiac biomarkers, while unhealthy plant foods raise heart disease risk. Key findings from a large study.

11 Jun 2025

Maternal iron deficiency disrupts embryonic sex determination in mice

Developmentally expressed genes play a fundamental role in the formation of a wide range of organs. The Y chromosome-located mammalian sex-determining gene Sry, required for the formation of testis, is activated only within a narrow time window during embryogenesis.

11 Jun 2025

Tufts researchers design new generation of weight loss medications

Weight loss drugs like Ozempic and Wegovy are used by over 15 million adults in the U.S., or 4.5% of the population. Despite their effectiveness, they have drawbacks.

11 Jun 2025

Targeting metabolic reprogramming in breast cancer treatment

Breast cancer remains the most prevalent malignancy among women worldwide, posing a critical challenge to global health.

11 Jun 2025

Uncovering the genetic link between type 2 diabetes and brain structure

Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder worldwide. Beyond glucose dysregulation, it exerts significant effects on the central nervous system.

11 Jun 2025

ISSCR updates guidelines for oversight and regulation of stem cell-based embryo models

The International Society for Stem Cell Research (ISSCR) Embryo Models Working Group has released updated recommendations for the oversight and regulation of stem cell-based embryo models (SCBEM), aiming to address rapid advancements and ensure responsible scientific progress.

11 Jun 2025

Eva1 targeted CAR T cells successfully eliminate tumors in preclinical study

CAR-T cells are specialized immune cells genetically modified to recognize and attack cancer cells. Researchers at Nagoya University in Japan and their collaborators have developed new CAR-T cells to target malignant tumors.

11 Jun 2025

Chromium-rich fiber supplement keeps you fuller and reduces insulin spikes

A single dose of a chromium-enriched glucomannan-fructo-oligosaccharide fiber complex significantly reduced postprandial insulin and increased fullness in healthy adults, without affecting blood glucose. These findings highlight the potential of this functional fiber blend to support appetite control and metabolic health.

10 Jun 2025

Scientists discover hundreds of new metabolites linked to the human microbiome

Human metabolism is a complex web of chemical processes and interactions between our cells and the microbes living within us.

10 Jun 2025

Protein ELAV identified as key regulator of circular RNAs in the brain

Deep within our nerve cells, a molecule is at work that has no beginning and no end. Instead of a straight chain, as is it common for most RNA strands, it forms a closed loop.

10 Jun 2025

Psilocybin rewires the brain for weeks, study finds

Psilocybin induces consistent and sustained changes in brain network connectivity, particularly between the hippocampus and default mode network, as shown using high-resolution fMRI in healthy adults. These neural effects, distinct from those produced by methylphenidate, may underlie the drug’s psychological benefits and were reproducible within individuals over time.

10 Jun 2025

When old diseases find new ways in: Europe’s latest diphtheria outbreak explained

A large multicountry outbreak of toxigenic Corynebacterium diphtheriae occurred among migrants entering Europe in 2022, driven primarily by cutaneous infections and involving multiple genetic lineages. Despite the unprecedented surge, transmission to resident populations was limited, but rising antimicrobial resistance and delayed treatment highlight ongoing public health risks.

10 Jun 2025

Eliminating stellate cells reduces liver metastasis in mouse models

The prestigious journal Hepatology Communications reports on the discovery by the Cancer and Translational Medicine research group of the University of the Basque Country (EHU).

10 Jun 2025